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Agenus plans to discovers and developes novel immuno-oncology targets using intensive use of bioinformatics to interrogate the transcriptome of human disease together with ex-vivo validation in diseased tissue to uncover new approaches to target key compartments of the immune system.

Oncology Pipeline

An Undisclosed anti-mouse KLRG1 antibody is in preclinical development, which neutralized the interaction of KLRG1 with its ligands. KLRG1 is a lymphocyte co-inhibitory receptor, expressed predominantly on effector memory CD8+ T cells and NK cells, whose ligands E- and N-cadherin are differentially expressed during epithelial-mesenchymal transition.

In animal studies in the 4T1 murine breast cancer model, anti-KLRG1 antibody as monotherapy reduced lung metastases compared to control antibody. Also, combination therapy anti-KLRG1 + anti-PD-1 produced synergistic benefit significantly greater than that of anti-PD-1 alone for tumor volume and survival with combination therapy.